:root{color-scheme:dark;--ink:#effffc;--muted:#a9c7c9;--night:#05131d;--deep:#082838;--teal:#42e3d1;--gold:#e9c36f;--line:rgba(157,235,224,.2);--danger:#ffb7a8;--recruiting:#22c55e;--rollout:#38bdf8;--review:#fbbf24;--closed:#fb923c;--terminated:#f87171;--preclinical:#c084fc;font-family:Inter,ui-sans-serif,system-ui,-apple-system,"Segoe UI",sans-serif}
*{box-sizing:border-box}
html{scroll-behavior:smooth}
body{margin:0;color:var(--ink);background:radial-gradient(circle at 82% 8%,rgba(58,196,208,.15),transparent 30rem),radial-gradient(circle at 12% 34%,rgba(205,155,80,.1),transparent 25rem),var(--night);line-height:1.55}
a{color:inherit}
.skip-link{position:fixed;z-index:100;top:10px;left:10px;width:1px;height:1px;padding:0;margin:-1px;overflow:hidden;clip:rect(0,0,0,0);clip-path:inset(50%);white-space:nowrap;border:0;background:#fff;color:#071e2d;font-weight:800;text-decoration:none}
.skip-link:focus{width:auto;height:auto;padding:11px 15px;margin:0;overflow:visible;clip:auto;clip-path:none;white-space:normal;border:2px solid var(--gold);border-radius:10px}
.sr-only{position:absolute!important;width:1px!important;height:1px!important;padding:0!important;margin:-1px!important;overflow:hidden!important;clip:rect(0,0,0,0)!important;white-space:nowrap!important;border:0!important}
a:focus-visible,button:focus-visible,input:focus-visible{outline:3px solid var(--gold);outline-offset:2px}
.site-head,main,footer{width:min(1180px,calc(100% - 32px));margin-inline:auto}
.site-head{display:flex;align-items:center;justify-content:space-between;padding:24px 0}
.brand{display:flex;align-items:center;gap:10px;text-decoration:none;font-weight:800;letter-spacing:.03em}
.brand span{display:grid;place-items:center;width:38px;height:38px;border:1px solid rgba(255,255,255,.26);border-radius:13px;background:linear-gradient(145deg,#087980,#075a65);box-shadow:0 10px 30px rgba(23,201,195,.18)}
.nav-links{display:flex;gap:16px;align-items:center}
.back{color:var(--muted);text-decoration:none}.back:hover,.back:focus-visible{color:var(--ink)}
.hero{position:relative;overflow:hidden;display:grid;grid-template-columns:minmax(0,1.3fr) minmax(260px,.7fr);gap:40px;align-items:center;min-height:480px;padding:64px clamp(24px,6vw,78px);border:1px solid var(--line);border-radius:34px;background:linear-gradient(145deg,rgba(8,42,56,.95),rgba(5,18,28,.94));box-shadow:0 35px 90px rgba(0,0,0,.32)}
.hero:after{content:"";position:absolute;inset:auto -12% -58% 25%;height:70%;background:conic-gradient(from 210deg,transparent,rgba(62,228,207,.12),rgba(234,191,100,.12),transparent);filter:blur(24px);pointer-events:none}
.hero-copy{position:relative;z-index:1}
.eyebrow,.num{margin:0 0 12px;color:var(--teal);font-size:.73rem;font-weight:800;letter-spacing:.18em;text-transform:uppercase}
h1,h2,h3,p{margin-top:0}
h1{max-width:760px;margin-bottom:20px;font-family:Georgia,"Times New Roman",serif;font-size:clamp(3rem,7vw,5.5rem);line-height:.95;letter-spacing:-.045em}
h1 em{color:var(--gold);font-weight:400}
.lede{max-width:720px;color:#c6dddd;font-size:clamp(1rem,2vw,1.18rem)}
.hero-actions,.visit-actions{display:flex;gap:12px;align-items:center;flex-wrap:wrap}
.button{display:inline-flex;align-items:center;justify-content:center;border:1px solid transparent;border-radius:999px;background:var(--teal);color:#031719;padding:12px 20px;font:inherit;font-weight:800;text-decoration:none;cursor:pointer}
.button.ghost{border-color:var(--line);background:rgba(255,255,255,.04);color:var(--ink)}
.button:hover,.button:focus-visible{transform:translateY(-1px);box-shadow:0 10px 28px rgba(24,208,198,.15)}
.signal{position:relative;z-index:1;width:min(100%,320px);aspect-ratio:1;margin:auto;border:1px solid rgba(130,238,224,.25);border-radius:50%;background:radial-gradient(circle,rgba(42,211,200,.18),rgba(3,15,25,.25) 56%,transparent 57%);box-shadow:inset 0 0 70px rgba(47,223,209,.08),0 0 80px rgba(39,191,185,.08)}
.signal span,.signal i,.signal b{position:absolute;inset:50% auto auto 50%;display:block;border-radius:999px;transform:translate(-50%,-50%)}
.signal span{width:42%;aspect-ratio:1;background:radial-gradient(circle at 36% 30%,#fff 0 2%,#9dfff4 4%,#16a6a4 25%,#052630 67%);box-shadow:0 0 45px rgba(76,238,221,.3)}
.signal i{width:72%;height:1px;background:linear-gradient(90deg,transparent,var(--gold),transparent);transform:translate(-50%,-50%) rotate(-21deg)}
.signal b{width:82%;aspect-ratio:1;border:1px solid rgba(232,195,111,.3);border-left-color:transparent;transform:translate(-50%,-50%) rotate(28deg)}
.boundary{display:grid;grid-template-columns:.42fr 1fr;gap:32px;margin:28px 0;padding:28px 32px;border-left:4px solid var(--gold);background:rgba(62,46,21,.28);border-radius:0 18px 18px 0}
.boundary strong{font-family:Georgia,serif;font-size:1.5rem}.boundary p{margin:0;color:#d6d5c9}
.search-wrap{margin:40px 0 24px}
.search-head{display:flex;justify-content:space-between;align-items:flex-end;gap:20px;flex-wrap:wrap;margin-bottom:20px}
.search-head h2{margin:0;font-family:Georgia,serif;font-size:clamp(1.8rem,3.5vw,2.8rem)}
.entry-count{margin:0;color:var(--muted);font-weight:700}
.search-controls{display:grid;gap:14px}
input[type="search"]{width:100%;border:1px solid rgba(176,232,225,.25);border-radius:14px;background:#061a26;color:var(--ink);padding:14px 18px;font:inherit;font-size:1.05rem}
.filter-pills{display:flex;gap:10px;flex-wrap:wrap}
.pill{border:1px solid var(--line);border-radius:999px;background:rgba(255,255,255,.03);color:var(--muted);padding:8px 16px;font:inherit;font-size:.86rem;font-weight:700;cursor:pointer;transition:all .15s}
.pill:hover{color:var(--ink);border-color:rgba(66,227,209,.4)}
.pill.active{background:var(--teal);color:#031719;border-color:transparent}
.cards-grid{display:grid;grid-template-columns:repeat(auto-fit,minmax(min(100%,350px),1fr));gap:20px;margin:24px 0 64px}
.research-card{display:flex;flex-direction:column;justify-content:space-between;border:1px solid var(--line);border-radius:22px;background:linear-gradient(145deg,rgba(9,40,52,.85),rgba(5,20,30,.9));padding:26px}
.research-card[hidden]{display:none}
.no-results{grid-column:1/-1;text-align:center;padding:48px 24px;background:rgba(9,40,52,.5);border:1px dashed var(--line);border-radius:20px;color:var(--muted)}
.no-results strong{display:block;font-size:1.15rem;color:var(--ink);margin-bottom:8px}
.no-results[hidden]{display:none}
.card-meta{display:flex;justify-content:space-between;align-items:center;gap:10px;margin-bottom:12px}
.level-tag{font-size:.72rem;font-weight:800;letter-spacing:.12em;text-transform:uppercase;color:var(--muted)}
.status-badge{font-size:.72rem;font-weight:800;letter-spacing:.08em;padding:4px 10px;border-radius:6px;text-transform:uppercase}
.status-recruiting{background:rgba(34,197,94,.18);color:var(--recruiting);border:1px solid rgba(34,197,94,.4)}
.status-rollout{background:rgba(56,189,248,.18);color:var(--rollout);border:1px solid rgba(56,189,248,.4)}
.status-planned{background:rgba(251,191,36,.18);color:var(--review);border:1px solid rgba(251,191,36,.4)}
.status-review{background:rgba(233,195,111,.18);color:var(--gold);border:1px solid rgba(233,195,111,.4)}
.status-closed{background:rgba(251,146,60,.18);color:var(--closed);border:1px solid rgba(251,146,60,.4)}
.status-completed{background:rgba(148,163,184,.15);color:#cbd5e1;border:1px solid rgba(148,163,184,.3)}
.status-terminated{background:rgba(248,113,113,.18);color:var(--terminated);border:1px solid rgba(248,113,113,.4)}
.status-unknown{background:rgba(251,146,60,.18);color:var(--closed);border:1px solid rgba(251,146,60,.4)}
.status-preclinical{background:rgba(192,132,252,.18);color:var(--preclinical);border:1px solid rgba(192,132,252,.4)}
.research-card h3{margin:0 0 6px;font-family:Georgia,serif;font-size:clamp(1.3rem,2.2vw,1.65rem);line-height:1.2;color:var(--ink)}
.avenue{font-size:.82rem;color:var(--teal);margin-bottom:14px;font-weight:700}
.card-body p{margin:0 0 10px;color:#c6dddd;font-size:.92rem;line-height:1.5}
.card-body strong{color:var(--ink)}
.limits{padding:10px 12px;border-left:3px solid var(--gold);background:rgba(233,195,111,.08);border-radius:0 8px 8px 0;margin-top:12px!important}
.card-footer{display:flex;flex-direction:column;gap:8px;margin-top:16px;padding-top:14px;border-top:1px solid rgba(255,255,255,.08)}
.source-date{font-size:.78rem;color:var(--muted)}
.text-link{display:inline-block;color:var(--gold);font-weight:700;text-decoration:none;font-size:.9rem}
.text-link:hover,.text-link:focus-visible{text-decoration:underline}
.visit-card{display:grid;grid-template-columns:.65fr 1.35fr;gap:40px;align-items:start;margin:48px 0;border:1px solid var(--line);border-radius:24px;background:linear-gradient(145deg,rgba(9,40,52,.85),rgba(5,20,30,.9));padding:32px}
.visit-card h2{margin:0;font-family:Georgia,serif;font-size:clamp(1.8rem,3.5vw,2.6rem)}
.visit-card ul{margin:0;padding-left:20px;color:#c5d8d9}
.visit-card li+li{margin-top:12px}
.visit-actions{margin-top:20px}
footer{display:flex;justify-content:space-between;gap:20px;padding:24px 0 44px;color:var(--muted);font-size:.82rem}
@media(max-width:850px){
  .hero{grid-template-columns:1fr;min-height:auto}
  .signal{width:min(66vw,260px)}
  .boundary,.visit-card{grid-template-columns:1fr}
}
@media(max-width:560px){
  .site-head,main,footer{width:min(100% - 20px,1180px)}
  .hero{padding:40px 20px;border-radius:24px}
  h1{font-size:clamp(2.6rem,14vw,4.2rem)}
  .boundary,.research-card,.visit-card{padding:20px}
  .nav-links{gap:10px}
  footer{display:block}
  footer span{display:block;margin-top:6px}
}
@media print{
  @page{margin:10mm}
  body{background:white;color:#111;font-size:10pt}
  .site-head,.hero,.signal,.hero-actions,.nav-links,footer,.search-controls,.visit-actions{display:none}
  .boundary{display:none}
  .cards-grid{display:block}
  .research-card{border:1px solid #ccc;border-radius:0;background:white;color:#111;padding:12pt;margin-bottom:12pt;break-inside:avoid}
  .research-card h3{color:#000;font-size:13pt}
  .card-body p,.avenue{color:#222;font-size:9pt}
  .status-badge{border:1px solid #666;color:#000;background:#eee}
  .limits{background:#f9f9f9;border-left-color:#333}
  .text-link{color:#003366}
}